2024 Thiotetronic acid

Thiotetronic acid

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August undefined, 2024

WebJan 1, 2024 · Third, we aim to functionally characterize the unprecedented biosynthesis of thiotetronic acid polyketide antibiotics and apply new biosynthetic reactions to extend the synthesis and bioengineering of novel molecules. And fourth, we will interrogate the antimicrobial activity and mechanism of new meroterpenoid, bipyrrole, and thiotetronate ... WebOct 24, 1995 · The α-thiotetronic acid 1 reacts with amines predominantly with ring opening to give polyfunctionalized ketones (2) which readily cyclize to α-tetramic acid amides (4a, …

Detection, Identification, and Occurrence of Thiotetronic Acids in ...

WebApr 10, 2024 · Our findings pave the way for future biochemical investigation of the biosynthesis of this structurally unique group of thiotetronic acid natural products. Supporting Information Volume 18, Issue 12. June 19, 2024. Pages 1072-1076. This article also appears in: ChemBioChem Readers‘ Choice 2024 ... WebThe 2D chemical structure image of Thiotetronic acid is also called skeletal formula, which is the standard notation for organic molecules. The carbon atoms in the chemical structure of Thiotetronic acid are implied to be located at the corner(s) and hydrogen atoms attached to carbon atoms are not indicated – each carbon atom is considered to be associated … dawn cattle feeders

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by ...

WebWe show the production of a group of unusual thiotetronic acid natural products, including the well-known fatty acid synthase inhibitor thiolactomycin that was first described over 30 years ago, yet never at the genetic level in regards to biosynthesis and autoresistance. This finding not only validates the target-directed genome mining ... WebThe 3-unsubstituted thiotetronic acid 33 is 100% enolic in [2 H 6]dimethyl sulfoxide and exists completely as the keto tautomer 41 in [2 H]chloroform.Ozonolysis of the thioether … WebApr 25, 1976 · Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others April 1976 Yakugaku zasshi journal of the Pharmaceutical Society of Japan 96(4 ... dawn cavanagh

Identification of Thiotetronic Acid Antibiotic

WebOct 12, 2015 · Using this improved TAR, two thiotetronic acid BGCs were proficiently and directly cloned with an efficiency of 20-75% and expressed heterologously in a model … WebOct 21, 2015 · We show the production of a group of unusual thiotetronic acid natural products, including the well-known fatty acid synthase inhibitor thiolactomycin that was … dawn cassidy kilbourne bessacarrWebMay 15, 2006 · Thiolactomycin (TLM, Fig. 1) is an antibacterial natural product with broad-spectrum activity originally isolated from a species of Nocardia. 1 The thiotetronic acid core structure and 5-position isoprene side chain of TLM are found in several other natural products including thiotetromycin, U68204, and 834-B1. 2 Thiotetronic acids inhibit fatty … gateway discs sports

"WebJan 31, 2024 · The inhibitory potency against V. mali fatty acid synthase agreed well with the in vitro antifungal activity. The molecular docking suggested that the 3-acylthiotetronic … " - Thiotetronic acid

Thiotetronic acid

Synthesis and structure–activity relationships of

WebThe antibiotic contains a thiotetronic acid in the molecule and possesses a selective activity against Bacteroides fragilis. A new antibiotic, thiotetromycin, has been isolated from the … WebApr 25, 1976 · Syntheses and Antitumor Activities of Derivatives of Tetramic Acid, Tetronic Acid and Thiotetronic Acid, and Others April 1976 Yakugaku zasshi journal of the …

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WebOct 5, 2015 · This paper demonstrates that electrospray ionization (ESI) with differential ion mobility spectroscopy (FAIMS) and “soft” mass spectrometry (MS) provide unique analytical capabilities that led to the discovery of sulfur-containing polar congeners of thiotetronic acid (TA) in drinking water from underground sources in Canada and the United States. Polar … WebIdentification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. Tang X, Li J, Millan-Aguinaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS ACS Chem Biol. 2015 Oct 21. PubMed Article Plasmids from Article. ID Plasmid Purpose ...

WebBGCs to a series of structurally rare thiotetronic acid fatty acid synthase inhibitors. RESULTS AND DISCUSSION Mining Salinispora BGCs for Putative Antibiotic Resistance Genes. We queried the genomes of 86 Salinispora strains (10 S. tropica,43S. arenicola, and 33 S. pacifica) for putative target modifying resistance genes associated with WebApr 1, 2024 · TLM (left), 3-acetyl thiotetronic acid lead (middle), and predicted docking pose (right) of 3-acetyl thiotetronic acid in a complex with C171Q KasA enzyme (Protein data bank (PDB): 4c6u).

WebOct 22, 2001 · 3-Acetyl analogues of thiolactomycin, a thiotetronic acid natural product, were synthesized and profiled against livestock pathogens.Some analogues showed … WebApr 10, 2024 · Our findings pave the way for future biochemical investigation of the biosynthesis of this structurally unique group of thiotetronic acid natural products. Citing Literature. Supporting Information Volume 18, Issue 12. June 19, 2024. Pages 1072-1076. This article also appears in: ChemBioChem Readers‘ Choice 2024 ...

WebSep 4, 2015 · Detection, Identification, and Occurrence of Thiotetronic Acids in Drinking Water from Underground Sources by Electrospray Ionization-High Field Asymmetric …

WebOct 1, 2001 · The UV absorption properties of several other pairs of thiotetronic acid ethers confirm that these differences are general features that provide a simple method for distinguishing between 2- and 4 ... gateway discovery utahWebNational Center for Biotechnology Information dawn cater gateway disposal holiday scheduleWebthiotetronic acid analogues bearing various functional groups at the C-3 (COR, CO2R) and C-5 (alkyl) positions of the thiolactone ring. Results and Discussion The proposed … gateway disposal trucksWebThiotetronic acid 98%; CAS Number: 51338-33-1; Synonyms: 2,4-Tetrahydrothiophenedione,4-Hydroxy-2(5H)-thiophenone; find Sigma-Aldrich-340227 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. IN EN. Applications Products Services Support. All Photos (1) 340227. dawn cavanaughWebMar 23, 2024 · Design, Synthesis, and Antifungal Activities of 3-Acyl Thiotetronic Acid Derivatives: New Fatty Acid Synthase Inhibitors. Journal of Agricultural and Food Chemistry 2024, 66 (4) , 1023-1032. DOI: 10.1021/acs.jafc.7b05491. Yuta Sadamitsu, Keiichi Komatsuki, Kodai Saito, and Tohru Yamada . dawn cavanaugh apqsWebAcylation of (3H,5H)-tetrahydrothiophene-2,4-dione (thiotetronic acid) with acetyl, propionyl, and valeryl chlorides followed by O-C isomerization in the presence of 4-dimethylaminopyridine or acetone cyanohydrin gave rise to 3-acetyl, 3-propanoyl, and 3-pentanoyl derivatives of thiotetronic acid.The reaction of 3-acylthiotetronic acids with … gateway disposal holiday schedule 2022