2024 Gas6 molecular weight

Gas6 molecular weight

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August undefined, 2024

WebMonoclonal Antibody for studying GAS6. Cited in 14 publications. Validated for WB, IHC, IF. Highly specific and rigorously validated in-house, GAS6 (D3A3G) Rabbit Monoclonal Antibody (CST #67202) is ready to ship. ... WebDepositor: Clinical Proteomics Technologies for Cancer. Host Species: rabbit. Antigen Sequence: Positive Tested Species Reactivity: Human. Depositors Institution: National Cancer Institute. Antigen Molecular Weight: 98.3 kDa. Depositors Notes: AXLp is the receptor for growth factor GAS6. AXLp is also a host cell viral receptor.

Corticosterone inhibits GAS6 to govern hair follicle stem-cell ... - Nature

WebSep 15, 2024 · Axl binds to a high affinity ligand growth arrest specific 6 (Gas6) that belongs to the vitamin K-dependent family of proteins. The Gas6/Axl signaling pathway has been implicated to promote progression, metastasis, immune evasion, and therapeutic resistance in many cancer types. WebFeb 20, 2012 · While the majority of Mer from control samples existed as a 180-kDa band, Gas6-treated cells predominantly expressed a form of Mer with a faster electrophoretic mobility and approximate molecular weight of 150 kDa. salary web designer ohio

Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors

WebJan 18, 2024 · Published 18 Jan 2024 Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological activities are mediated by the interaction with three tyrosine kinase receptors: Tyro3, Axl, and MerTK, which are commonly and collectively abbreviated as TAM [ 4 ]. WebNov 4, 2024 · Although full-length AXL contains 894 amino acids and encodes a predicted protein of 98 kDa, the actual observed molecular weight ranges from 100 to 140 kDa … WebAnti-GAS 6 antibody (ab136249) Datasheet SDS Reviews ( 3) Submit a question References (4) Key features and details Rabbit polyclonal to GAS 6 Suitable for: WB Reacts with: Human Isotype: IgG You may also be … things to do in houston january 2023

Role of the Gas6/TAM System as a Disease Marker and Potential ... - Hindawi

Characterization of Gas6, a Member of the Superfamily of G …

WebMar 24, 2005 · Gas6 was demonstrated to be present in human plasma, at a concentration determined to be 13 to 23 ng/mL (0.16 to 0.28 nM). Furthermore, plasma Gas6 levels … Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. salary walgreens pharmacistWebJun 18, 2024 · Although the molecular weight of the full-length Axl is 104 kDa, post-translational modifications of the extracellular domains give rise to two modified forms … things to do in houston late night

"WebFeb 3, 2024 · Here, we tested the hypothesis that expression of growth arrest–specific 6 (GAS6), the ligand of receptor tyrosine kinase AXL, is associated with chemotherapy response and that sequestration of GAS6 with AVB-S6–500 (AVB-500) could improve tumor response to chemotherapy and PARP inhibitors. " - Gas6 molecular weight

Gas6 molecular weight

GAS6 Protein Overview: Sequence, Structure, Function and Protein ...

WebOct 4, 2016 · For GAS6 kinetics upon AXL inhibition, cells were serum-starved overnight and preincubated with GI 50 non-Mes or GI 50 Mes concentrations of R428 for an hour, … WebApr 10, 2024 · Activation of AXL Receptor and its ligand GAS6 is a major mechanism of acquired resistance to EGFR-TKIs therapy ... Moreover, due to its relatively large molecular weight, the concentration of drug in tumors is limited. Study suggested only a small portion of ADCs could reach to the tumor cells.

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WebAnti-GAS6 Antibody detects endogenous levels of total GAS6 protein. Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein, that has a molecular weight of 75kDa. It is located on human chromosome 13q34. WebSuitable for use as control antibody for Gas6 siRNA (h): sc-35450, Gas6 shRNA Plasmid (h): sc-35450-SH and Gas6 shRNA (h) Lentiviral Particles: sc-35450-V. Molecular Weight of Gas6: 85 kDa. Positive Controls: Gas6 (h): 293T Lysate: sc-115479, SH-SY5Y cell lysate: sc-3812 or SK-N-SH cell lysate: sc-2410. RECOMMENDED SUPPORT REAGENTS

WebApr 29, 2024 · Figure 1 shows the ROC curve referred to baseline Gas6 levels: considering an area under the curve of 0.653, we identified a Gas6 level of 58.0 ng/ml as the cut-off predicting a more severe disease evolution (53.33% sensitivity and 77.57% specificity), with a likelihood ratio of 2.38 (IQR: 1.46-3.87). Figure 1 WebGas6 is present at around 0.2 nM (18 ng mL−1) in normal human serum or plasma [4], whereas the anticoagulant protein S is present at a thousand-fold higher concentration …

WebJan 18, 2024 · Growth arrest-specific 6 (Gas6) is a gene cloned in 1993 [ 1] encoding for a vitamin K-dependent protein expressed in different tissues [ 1 – 3 ]. Its biological … WebMar 8, 2024 · TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poor …

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WebGas6 is present at around 0.2 nM (18 ng mL−1) in normal human serum or plasma [4], whereas the anticoagulant protein S is present at a thousand-fold higher concentration [5]. Gas6 binds and activates the three members of the TAM-family of receptor tyrosine kinases comprising Tyro3, Axl and Mer [6,7]. things to do in houston birthdayWebMar 23, 2024 · Since growth arrest-specific gene 6 (Gas6) was discovered in 1988, numerous studies have highlighted the role of the Gas6 protein and its receptors Tyro3, Axl and Mer (collectively referred to as TAM), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggreg … salary warriorWebSep 21, 2014 · A combination of biochemical and structural studies was used to elucidate the molecular mechanism for high-affinity Gas6 binding. ... 1 mg per kg body weight dose of MYD1 Fc, and free Gas6 levels ... salary washington state employeeWebGAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human … things to do in houston this sundayWebFor experiments assaying the requirement for a GAS6 gradient, cells containing 200 ng/ml GAS6 in DMEM-H were placed in the upper well of the chamber (GAS6/U&L). Following … salary web designer kingsport eastmanWebCalculated molecular weight: 678 aa, 75 kDa: Observed molecular weight: 75 kDa: GenBank accession number: BC038984: Gene symbol: GAS6: … salary wayne state universityWebGas6, which is maximally expressed at stage VI, may encode an autocrine factor for Sertoli cells because they express GAS6 receptors and respond to this cytokine with increased … things to do in houston june 2023