WebCollismycin B C13H13N3O2S CID 135474257 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... WebDec 6, 2016 · Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report …
吡啶-2-胺衍生物及其药物组合物和用途专利检索-·对白血病有特异 …
WebNov 23, 2024 · In addition, collismycin C suppressed TGFBIp-induced sepsis lethality and pulmonary injury. This suppression of TGFBIp-mediated and CLP-induced septic responses indicates that collismycin C is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the … We began by reconstituting the activities of the didomain NRPS CaeA1 (650-aa), the PKS-NRPS hybrid CaeA2 (2484-aa), and the single-module NRPS CaeA3 (1047-aa) in vitro (Fig. 2). These multifunctional enzymes were individually produced in an engineered Escherichia coli strain expressing Sfp26,27, a … See more Phylogenetically, CaeB1 is close to flavin-dependent dehydrogenases, particularly, those acting on acyl thioester substrates (Supplementary … See more We then examined the elongated intermediate covalently tethered to the PCP domain of CaeA2 during 1 formation. The incubation of CaeA1, CaeA2F2042L, and CaeB1 with picolinic acid, malonyl-CoA, and l-cysteine … See more Notably, CaeB1 activity strictly depends on the Ct domain of CaeA2, a C-like domain that is shortened by ~1/3 and lacks the catalytic l-histidine residue (Supplementary … See more Focusing on the timing of the dethiolation step, we attempted to dissect the specific 2,2’-bipyridine-forming process in the CAE assembly line (Fig. 5). Omitting CaeA1 for picolinic acid … See more イウォーク 槍
[PDF] Laccase-catalysed biotransformation of collismycin …
WebThe present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease. WebDec 8, 2024 · Here, we report that caerulomycin and collismycin peptide-polyketide hybrid antibiotics share an unusual assembly line that involves NRPS activity to recruit a flavoprotein acting in trans and catalyze C-C bond formation and heterocyclization during 2,2’-bipyridine formation. Simultaneously, this assembly line provides dethiolated and ... Web本文尤其公开了用于抑制Taspase1和治疗癌症的化合物和方法。 イヴォーク 窓